The Bradykinin Hypothesis

[Joe Guy]

A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.

When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a “eureka moment.” The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson’s group published their results in a paper in the journal eLife in early July. click here for the rest of the article....

[Gob]

Very interesting read!! Thanks for sharing.

[ex-khobar Andy]

There was a piece in yesterday's NYT about how those pesky commies (Chinese and Russian) are trying to steal 'our' COVOID research. The responses were almost all along the lines of - WTF? Why is this not an international effort with transparency all the way so that everyone knows about the good stuff (what works) and the bad stuff (don't waste your time down this blind alley)? The answer of course is obvious and it's not just Trump but $$$$$$$$$ and international prestige.

So it's nice to see a journal piece - I read it but I don't pretend to even begin to understand the science - from multiple US sources published in a Dutch on-line journal. Oak Ridge National Laboratory is DoE funded (descended from the Manhattan Project), plus Universities of Cincinnati, Tennessee and Kentucky and Yale. Money from NIH.