Getting vaccinated

[TPFKA@W]

do you have a will and/or a trust

Yes. The rugbrats will have good educations and a few charities will be pleased when I croak. I am sorry Joe, you did not make the cut for my proceeds.

[Joe Guy]

Okay, I know now that you're leaving money to tripped toddlers but I hope you're also leaving something for kicked puppies.

[Burning Petard]

I guess I got the wrong version--no near death experience. However I AM fully vaccinated. Does that now make me subject to arrest for performing abortions in some states, just by walking around?

snailgate

[TPFKA@W]

I guess I got the wrong version--no near death experience. However I AM fully vaccinated. Does that now make me subject to arrest for performing abortions in some states, just by walking around?

snailgate

Hyperbole my friend but I am quite achy and miserable tonight and it came on quicker than last time.

[Gob]

Getting my second jab next week, (Weds.)

[TPFKA@W]

That was a rather miserable 24 hours but I seem to be on the mend. I wonder if the future annual vaccine will also be miserable.

[Joe Guy]

Glad to hear you're feeling better. That's a good question too.

[Long Run]

I was going to say, that if there are future vaccinations, you might want to see about switching over to Pfizer or Johnson & Johnson.

[MGMcAnick]

I was going to say, that if there are future vaccinations, you might want to see about switching over to Pfizer or Johnson & Johnson.

I thought switching vaccines was not supposed to be a good idea.

Mrs Mc finally got an appointment to get the J&J vaccine a couple of weeks ago. Absolutely no side effects other than the standard sore shoulder.

[Long Run]

I was going to say, that if there are future vaccinations, you might want to see about switching over to Pfizer or Johnson & Johnson.

I thought switching vaccines was not supposed to be a good idea.

Certainly that makes sense during this initial period. But if there are future COVID vaccines they will be different to address the mutations, so I would think you could shift to another provider a year or more from now. I would hate to think that I am a Pfizer man for the rest of my life!

[Joe Guy]

Just saw Dr Peter McCullough (a cardiologist) on Faux News talking about how people are being "coerced" into getting the COVID vaccine and that children risk dying by getting vaccinated. Some other jerk on there was saying how irresponsible Dr Fauci was when he said (in a video clip shown) that he would want his grandchildren to be vaccinated.

Also, I now believe that when Laura Ingraham was an infant she was breast-fed milk with lead in it.

[Gob]

I was rather hoping for a different jab next time.

A major UK trial looking at whether Covid vaccines can be mixed with different types of jabs used for first and second doses is being expanded.

Combining vaccines might give broader, longer-lasting immunity against the virus and new variants of it, and offer more flexibility to vaccine rollout.

Adults over 50 who have had a first dose of Pfizer or AstraZeneca can apply to take part in the Com-Cov study.

Their second dose could be the same again, or a shot of Moderna or Novavax.

Chief investigator on the trial Prof Matthew Snape, from the Oxford Vaccine Group, said he hoped to recruit 1,050 volunteers who had already received one dose on the NHS in the past eight to 12 weeks.

More than 800 people are already taking part in the research and have received two doses of either Pfizer, AstraZeneca or a mix.

https://www.bbc.co.uk/news/health-56730526

[Long Run]

Go for it and let us know how it works out you.

I was rather hoping for a different jab next time.

Adults over 50 who have had a first dose of Pfizer or AstraZeneca can apply to take part in the Com-Cov study.

[TPFKA@W]

Today I felt an unusual compulsion to vote socialist and a magnet stunk to my arm where they put the chip.

[Econoline]

a magnet stunk to my arm where they put the chip.

Damn, those stinky magnets are the worst....

[TPFKA@W]

Well at least THAT aspect of my life was not altered by Biden's chip implants.

[Scooter]

Go for it and let us know how it works out you.

Early data suggests that it's a good strategy:

Mix-and-Match COVID Vaccines Trigger Potent Immune Response

Vaccinating people with both the Oxford–AstraZeneca and Pfizer–BioNTech COVID-19 vaccines produces a potent immune response against the virus SARS-CoV-2, researchers conducting a study in Spain have found.

Preliminary results from the trial of more than 600 people — announced in an online presentation on May 18 — are the first to show the benefits of combining different coronavirus vaccines. A UK trial of a similar strategy reported safety data last week, and is expected to deliver further findings on immune responses soon.

Because of safety concerns, several European countries are already recommending that some or all people who were given a first dose of the vaccine developed by the University of Oxford, UK, and AstraZeneca in Cambridge, UK, get another vaccine for their second dose. Researchers hope that such mix-and-match COVID-19 vaccination regimens will trigger stronger, more robust immune responses than will two doses of a single vaccine, while simplifying immunization efforts for countries facing fluctuating supplies of the various vaccines.

“It appears that the Pfizer vaccine boosted antibody responses remarkably in one-dose AstraZeneca vaccinees. This is all around wonderful news,” says Zhou Xing, an immunologist at McMaster University in Hamilton, Canada.

Starting in April, the Spanish CombivacS trial enrolled 663 people who had already received a first dose of the Oxford–AstraZeneca vaccine, which uses a harmless chimpanzee ‘adenovirus’ to deliver instructions for cells to make a SARS-CoV-2 protein. Two-thirds of participants were randomly picked to receive the mRNA-based vaccine made by Pfizer, based in New York City, and BioNTech, in Mainz, Germany, at least eight weeks after their first dose. A control group of 232 people has not yet received a booster. The study was led by the Carlos III Health Institute in Madrid.

The Pfizer–BioNTech booster seemed to jolt the immune systems of the Oxford–AstraZeneca-dosed participants, reported Magdalena Campins, an investigator on the CombivacS study at the Vall d’Hebron University Hospital in Barcelona, Spain. After this second dose, participants began to produce much higher levels of antibodies than they did before, and these antibodies were able to recognize and inactivate SARS-CoV-2 in laboratory tests. Control participants who did not receive a booster vaccination experienced no change in antibody levels.

That is what researchers hoped for and expected from mixing different vaccines, a strategy known as a heterologous prime and boost, which has been deployed for vaccines against other diseases, such as Ebola. “These responses look promising and show the potential of heterologous prime–boost regimens,” says Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston, Massachusetts.

Xing says the antibody response to the Pfizer boost seems to be even stronger than the one most people generate after receiving two doses of the Oxford–AstraZeneca vaccine, according to earlier trial data. But it is not clear how those responses compare with those seen in people who receive two doses of mRNA vaccines such as Pfizer–BioNTech’s, which tend to trigger an especially potent antibody response after a second dose.

Making such comparisons is “apples and oranges”, says Daniel Altmann, an immunologist at Imperial College London. A strong immune response to the mix-and-match strategy is “entirely predictable from the basic immunology”, he adds.

Giving people first and second doses of different vaccines probably makes sense, says Altmann. But he wonders what will happen if people need a third dose to prolong immunity or protect against emerging coronavirus variants. Repeated doses of virus-based vaccines such as the Oxford–AstraZeneca one tend to be increasingly less effective, because the immune system mounts a response against the adenovirus. RNA vaccines, by contrast, tend to trigger stronger side effects with added doses. “I do think there’s a brave new world of vaccinology to be scoped in all of this,” Altmann says.

Last week, a UK study called Com-COV, which analysed combinations of the same two vaccines, found that people in the mix-and-match groups experienced higher rates of common vaccine-related side effects, such as fever, than did people who received two doses of the same vaccine. In the Spanish CombivacS trial, mild side effects were common, and similar to those seen in standard COVID-19 vaccine regimens. None was deemed severe.

[Burning Petard]

To Long Run and others who prefer not to be used as a lab test animal.

The dirty little secret is that medical science never knows the actual or potential effects of a drug or chemical until it is finally in use by large numbers of people.

Rarely is a drug intentionally tested on pregnant humans. Thalidomide is a useful treatment for anxiety and some cancers, as long as you are not pregnant. Aspirin and coffee would never make it to market today because they both have very nasty effects in common lab animals; they would be classed as way too toxic for humans, but those do not show up in humans.

snailgate

[Bicycle Bill]

-"BB"-

[Econoline]